Animal reproduction studies haven't been carried out While using the drug combination–promethazine and phenylephrine. It is far from recognised whether or not this drug combination may cause fetal hurt when administered into a Expecting lady or can have an effect on replica capability. Promethazine and phenylephrine should be presented to a Expecting female provided that Plainly essential.
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It truly is freely soluble in water and Liquor. Phenylephrine hydrochloride is issue to oxidation and should be protected from gentle and air. It's a molecular weight of 203.67, a molecular formula of C9H13NO2 • HCl, and the next structural system:
Akorn lean refers to the misuse of Akorn promethazine-codeine syrup in lean drinks. People combine the syrup with soda and sweet to produce a sweet, sedative beverage.
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Phenylephrine: A research in rabbits indicated that continued reasonable overexposure to phenylephrine (three mg/working day) during the second 50 percent of pregnancy (twenty second day of gestation to supply) may well add to perinatal wastage, prematurity, untimely labor, And perhaps fetal anomalies; when phenylephrine (three mg/working day) was specified to rabbits throughout the initial fifty percent of pregnancy (third day after mating for seven days), a big quantity gave delivery to litters of lower beginning excess weight.
Promethazine HCl and codeine phosphate oral Option is indicated for click here that momentary reduction of coughs and upper respiratory signs connected with allergy or even the typical cold in people eighteen several years of age and older.
Pregnancy Assessments: Diagnostic pregnancy assessments based upon immunological reactions concerning HCG and anti-HCG may end in Phony-negative or false-good interpretations.
Hello-Tech Pharmaceuticals is often a notable title during the pharmaceutical business, recognized for producing a variety of medicines and health supplements, including promethazine and codeine syrup.
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Promethazine is metabolized by the liver to several different compounds; the sulfoxides of promethazine and N-demethylpromethazine tend to be the predominant metabolites appearing during the urine.
Promethazine hydrochloride and phenylephrine hydrochloride syrup must be utilised with caution in pediatric patients two yrs of age and older (see WARNINGS-Use in Pediatric Individuals)